Muon tomography allows investigating the subsurface. Muons being penetrative, the attenuation of the muon flux depends on the quantity of matter the particles travel through, hence on the rock density and thickness. For the Temporal Tomography of rock Density using Muon Measurements (T2DM2) project, the muon flux measurements are performed in LSBB URL (http://www.lsbb.eu) in order to study the hydrogeological processes in the unsaturated area of Fontaine-de-Vaucluse karst aquifer. The suitability of the muography for this study is here numerically demonstrated. In parallel to these simulations, muon flux measurements are carried out in the LSBB galleries by means of a set of four scintillator tanks and Micromegas detectors are developed. These detectors, here described, are adapted for underground and confined spaces as well as other environments. Their performances are particularly interesting and should contribute to the expansion of muon tomography in new application fields.