LINAC 4 is a normal conducting H- linac which aims to intensify the proton flux available for the CERN accelerator complex. This injector is designed to accelerate a 65 mA beam of H- ions up to 160 MeV for injection into the CERN Proton Synchrotron Booster. The acceleration is done in three stages : up to 3 MeV with a Radio Frequency Quadrupole (the IPHI RFQ) operating at at 352 MHz, then continued to 90 MeV with drift-tube structures at 352 MHz (conventional Alvarez and Cell Coupled Drift Tube Linac) and, finally, with a Side Coupled Linac at 700MHz. The accelerator is completed by a chopper line at 3 MeV and a transport and matching line to the PS booster. After the overall layout was determined based on general consideration of beam dynamics and RF, a global optimisation based on end-to-end simulation has refined some design choices. The results and lessons learned from the end-to-end simulations are reported in this paper.