Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency - IN2P3 - Institut national de physique nucléaire et de physique des particules Access content directly
Journal Articles Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms Year : 2009

Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency

Abstract

Ion-induced cell killing has been reported to depend on the irradiation dose but also on the projectile parameters. In this paper we focus on two approaches developed and extensively used to predict cell survival in response to ion irradiation: the Local Effect Model and the Katz Model. These models are based on a track-structure description summarized in the concept of radial dose. This latter is sensitive to ion characteristics parameters and gives to both models the ability to predict some important radiobiological features for ion irradiations. Radial dose is however an average quantity, which does not include stochastic effects. These radiation-intrinsic effects are investigated by means of a Monte-Carlo simulation of dose deposition. We show that both models are not fully consistent with the nanometric and microscopic dose deposition statistics.
Fichier principal
Vignette du fichier
NIMB_GMontarou_2009.pdf (235.08 Ko) Télécharger le fichier
Origin Files produced by the author(s)
Loading...

Dates and versions

in2p3-00363079 , version 1 (20-02-2009)

Identifiers

Cite

Michaël Beuve, Anthony Colliaux, Djamel Dabli, Denis Dauvergne, B. Gervais, et al.. Statistical effects of dose deposition in track-structure modelling of radiobiology efficiency. Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms, 2009, 267, pp.983-988. ⟨10.1016/j.nimb.2009.02.016⟩. ⟨in2p3-00363079⟩
51 View
111 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More