Vector-like quarks are an essential ingredient of many extensions of the Standard Model of particle physics. Moreover the presence of more than one vector-like multiplet is a common situation in many models. The interplay of these vector-like multiplet with precision electroweak bounds, flavour and collider phenomenology, especially at the Large Hadron Collider is a important point for the discovery of physics beyond the standard model. I consider the presence of two vector-like multiplets in order to show the constraints on such scenarios from tree-level data and oblique corrections in the case of a completely general flavour mixings with all the three standard model families of quarks. I also describe a framework for studying the interplay of any number of vector-like multiplets.