The comparison of the results of direct detection of Dark Matter, obtained with various target nuclei, requires model-dependent, or even arbitrary, assumptions. Indeed, to draw conclusions either the spin-dependent (SD) or the spin-independent (SI) interaction has to be neglected. In the light of the null results from supersymmetry searches at the LHC, the squark sector is pushed to high masses. We show that for a squark sector at the TeV scale, the framework used to extract contraints from direct detection searches can be redefined as the number of free parameters is reduced. Moreover, the correlation observed between SI and SD proton cross sections constitutes a key issue for the development of the next generation of Dark Matter detectors.